p62 works as a hub modulation in the ageing process

p62 app  Reduction of p62 protein levels or interference with p62 function significantly increased cell death that was induced by the expression of mutant huntingtin We New evidence supports an autophagy-independent key role of the adaptor p62 in signaling functions central to tumor initiation

Reduction of p62 protein levels or interference with p62 function significantly increased cell death that was induced by the expression of mutant huntingtin We Supported Radio Models¶ · H777 · H777 · H777 Plus · H777S · P2 · P62 · RA685 · RA79

Overproduction In humans, the loss of p62 caused damages to the central nervous system without other organs affected  p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed APP P05067, 6, EBI-307104, EBI-77613 XENO, Q13501 · ATG8 P38182, 3, EBI-307104, EBI